(1)肝功能损伤:一些皮肤病(主要是湿疹或牛皮癣)患者在服用中草药后,出现了肝功能异常。据 <<lancel>>和<<British jounal of medicine>>等权威医学杂志报导(3-7),有六例均为服用中草药后出现肝功能异常(其毒性成分曾被怀疑是白藓皮)。多为个案报导。多数病人有恶心,疲劳,黄疸等症状,血检提示其肝功能异常一多由biliruhin,AIK,AST,ALT及B一超,活检等指标异常所证实。其中二例因肝功能异常行肝移植手术未获成功而死亡。其余患者均在停服中药后肝功能恢复正常。其中一例在肝功能恢复正常后继续服用中药,肝功能又不正常;再次停用中药,肝功能又恢复正常。无一例形成慢性持续性肝病的报导。
(3)充血性心力衰竭:1997年<<British.journal of Dermatology>>报导(11)在曼彻斯特一妇女服用中药治疗湿疹;二周后出现充血性心力衰竭,被诊断为中毒性心肌病。尽管此患者有甲状腺中毒症与阵发性心动过速的既往史,但诸症在近2-3年一直控制良好并无发作。其所服毒性成分被怀疑是甘草。大剂量甘草被认为促进钠的贮留和钾的流失,从而导致水与电介质的紊乱。对此类易感患者,水液贮留于心肌引起心肌病与心衰发生。该患者经过强心,利尿等西医常规治疗,三周盾病变完全控制。
1. sheehan, et al A controled trial of traditional chinese medicinal plants inWideSpread non-exudative atopic eczema,BJD, 1992 126: 179
2. sheehan, et al Efficacy of traditional chinese herbal therapy in adult atopicdermatitis, The Lancet, 1992, 340: 13
3, Allen B R Chinese herbs for Eczema, The Lancet, 1990, 336: 177
4. Perharic-Walton L, Toxicity of Chinese herbal remedies, The Lancet, 1992,340 :674
5. Garham-Brown, Toxicity of chinese herbal remedies, The Lancet, 1992, 340:673
6. Vaulier G, Safety of Complementary medicine should be monitored, BMJ 1995 311: 633
7. Davies E G, Chinese herbs for Eczema, The Lancet, 1992, 336: 177
8. Vanherweghem JL, Rapidly Progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs; The Lancet, 1993; 341; 387
9. Vanhenweghem J L, Misuse of herbal remedies: the case of an outbreak of termonal renal failure in Belgium,J Alterm Complement Med, 1998, 4; 9
10. Graham M L, Nephropathy caused by Chinese herbs in the UK, The Lancet, 1999, 354
11, Ferguson J E, Reversible dilated cardiomyopathy following treatment Of atopic eczema with chinese medicine BJD,1997,136:592
12. Huang Wen, Chinese medicine treating eczema, JATCM, 1996, 513.浙江中医杂志, 1965