http://glittermonkey.com/blog/posts/166.aspx
Modifying GAC permissions To do this on the assembly folder you have to unregister shfusion.dll. Here are the steps
A. Unregister shfusion.dll to allow you access to the Security tab i) Select Start ii) Select Run iii) Type regsvr32 -u C:\WINNT\Microsoft.NET\Framework\v1.1.4322\shfusion.dll (or regsvr32 -u C:\WINNT\Microsoft.NET\Framework\v1.0.3705\shfusion.dll)
B. In a Windows Explorer, right click c:\winnt\assembly i) Select Properties ii) Select the Security Tab iii) <do what you need to do here>
C. Reregister the shfusion.dll to deny access to the Security Tab on the assembly folder. i) Select Start ii) Select Run iii) Type regsvr32 C:\WINNT\Microsoft.NET\Framework\v1.1.4322\shfusion.dll (or regsvr32 C:\WINNT\Microsoft.NET\Framework\v1.0.3705\shfusion.dll)

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